News on Wellness

New Study to Enhance the Combat Effects of Penicillin!


Penicillin was first discovered in 1928, and commercially put to use in the First World War as a powerful antibiotic is proving ineffective to combat multi resistant bacterial infections lately. The researchers from University of South Carolina have devised a new approach to enhance the qualities of penicillin so to combat multi resistant species also nick named ‘super bugs’.


Penicillin and related family of drugs were used in wide scale amounts in 1940s. Penicillin was first brought into picture for treating infection arising due to Staphylococcus aureus. In 1960 a new strain turned into endemic which was a resistant form of S.aureus. It was termed as MRSA, Methicillin resistant Staphylococcus aureus, which was multi drug resistant variant. Physicians often faced a grave problem in treating infected patients as this new strain was ineffective to the earlier administered antibiotics.

The MRSA strain of S. aureus is resistant to variety of defenses against antibiotics. One of the varieties of defenses neutralizes the intrinsic property of penicillin itself.  The core molecule of penicillin has a beta lactum ring. The four membered amide ring is the common structural component for synthetic and semi-synthetic derivatives of antibiotics. Bacterial defense system utilizes beta lactamase enzymes for dissolving the beta lactam ring. The new class of anti biotic resistant strains has evolved and can now develop beta lactamase enzyme whenever needed which makes it more difficult to destroy. The new approach is to pair this drug with another polymer to enhance the protective role. The antimicrobial effectiveness of the four beta-lactams studied in detail was enhanced by the polymer.

The findings of this research have been published in the Journal of the American Chemical Society.  This new approach was develop by researchers namely Chuanbing Tang and graduate student Jiuyang Zhang who prepared cobaltocenium metallopolymer which greatly shows the destructiveness of beta lactamase. The polymer enhanced the antimicrobial effectiveness of the four beta-lactams. This study if established will be a remarkable discovery to combat resistant species of bacteria and enhance the functionality of penicillin.

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