News on Wellness

DNA Testing Reveals Risk to Prostate Cancer with Accuracy

DNA Testing

Cancer originating in prostate is usually restricted to the place of origin, and treated with surgery and radiotherapy. There are however chances of spreading, in cases of delay in therapy where the cancer is undetected for initial 2 to 3 years. Usually in such cases, cancer reoccurs in 30-50% of patients, due to malignancy spread to other body cells.  Researchers from the Princess Margaret Cancer Centre and the University of Toronto, headed by Dr. Robert Bristow have devised a new test which can detect the people prone to recurrence of prostate cancer. The findings for the same were presented at the, 33rd conference of the European Society for Radiotherapy and Oncology in Vienna.

DNA Testing

For conducting this study, prostate tissue samples were taken from two groups of men. First group consisted of 126 men who had undergone image-guided radiotherapy (IGRT) treatment for cancer restricted to only prostate. Array comparative genomic hybridization was conducted to screen the genome for defective genes and mutation study along with hypoxia or oxygen content of the tumor was analyzed. The second group was of 150 men who had undergone radical prostatectomy to remove their tumor. The tumor’s oxygen content and genetic signature were observed.

The conclusions were drawn from this study. The subjects with less genetic changes and lower oxygen in their tumor were less likely to experience recurrence of cancer in the next five years. They had 93% chances of surviving without further treatment for a while. Participants who had higher levels of gene alterations and more oxygen content in their tumor had high risk of recurrence, with 49% chances of survival in the next five years without treatment.

In US alone more than 2 lakh cases of prostate cancer has been reported this year. Even for patients with fears of having cancer spread, chemotherapy and hormone therapy are administered to control cancer. With initiatives like this test, prostate cancer could be better understood and dealt with in future.


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